0001193125-08-260052 Sample Contracts

PATENT AND LICENSE SECURITY AGREEMENT
Patent and License Security Agreement • December 24th, 2008 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • New York

This PATENT AND LICENSE SECURITY AGREEMENT (this “Agreement”), dated as of December 22, 2008, is by and between GTC BIOTHERAPEUTICS, INC. (“Grantor”) and LFB BIOTECHNOLOGIES S.A.S.U. (“Grantee”).

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TRADEMARK AND LICENSE SECURITY AGREEMENT
Trademark and License Security Agreement • December 24th, 2008 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Connecticut

This TRADEMARK AND LICENSE SECURITY AGREEMENT (this “Agreement”), dated as of December 22, 2008, is by and between GTC BIOTHERAPEUTICS, INC. (“Grantor”) and GENERAL ELECTRIC CAPITAL CORPORATION (“Grantee”).

SECURITY AGREEMENT
Security Agreement • December 24th, 2008 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances)

THIS SECURITY AGREEMENT (this “Agreement”) dated as of the 22nd day of December, 2008, from GTC BIOTHERAPEUTICS, INC. (“Debtor”) in favor of LFB BIOTECHNOLOGIES S.A.S.U. (together with its successors and assigns, if any, “Secured Party”). Secured Party has an office at 3, avenue des Tropiques, Les Ulis, Courtaboeuf, France. Debtor is a corporation organized and existing under the laws of the state of Massachusetts (the “State”). Debtor’s mailing address and chief place of business is 175 Crossing Blvd., Framingham, MA 01702.

GTC BIOTHERAPEUTICS, INC. AND AMERICAN STOCK TRANSFER AND TRUST COMPANY AS RIGHTS AGENT AMENDMENT No. 2 TO SHAREHOLDER RIGHTS AGREEMENT
Shareholder Rights Agreement • December 24th, 2008 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts

This SECOND AMENDMENT TO SHAREHOLDER RIGHTS AGREEMENT dated as of December 22, 2008 (the “Amendment”) is between GTC Biotherapeutics, Inc., a Massachusetts corporation formerly known as Genzyme Transgenics Corporation (the “Company”), and American Stock Transfer and Trust Company, a banking organization organized under the laws of New York, as Rights Agent (the “Rights Agent”).

CONSENT AND AMENDMENT NO. 3 TO AMENDED AND RESTATED MASTER SECURITY AGREEMENT
Master Security Agreement • December 24th, 2008 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Connecticut

THIS CONSENT AND AMENDMENT NO. 3 TO AMENDED AND RESTATED MASTER SECURITY AGREEMENT (this “Amendment”) dated as of the 22nd day of December, 2008, by and between GTC BIOTHERAPEUTICS, INC. (“Debtor”) and GENERAL ELECTRIC CAPITAL CORPORATION (together with its successors and assigns, if any, “Secured Party”).

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