0001193125-08-203995 Sample Contracts

Warrant to Purchase Common Stock of ISTA PHARMACEUTICALS, INC.
Ista Pharmaceuticals Inc • September 30th, 2008 • In vitro & in vivo diagnostic substances • New York

[ ] (“[ ]”) intends to transfer Warrants (the “Warrants”) of the Company to (“ ”) without registration under the Securities Act of 1933, as amended (the “Securities Act”). In connection therewith, we have examined and relied upon the truth of representations contained in an Investor Representation Letter attached hereto and have examined such other documents and issues of law as we have deemed relevant.

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REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • September 30th, 2008 • Ista Pharmaceuticals Inc • In vitro & in vivo diagnostic substances • New York

REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of September 26, 2008, by and between ISTA PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and those lenders set forth on Schedule 1 to the Facility Agreement (as defined below) (individually a “Lender” and together, the “Lenders”).

SECURITY AGREEMENT
Security Agreement • September 30th, 2008 • Ista Pharmaceuticals Inc • In vitro & in vivo diagnostic substances • New York

SECURITY AGREEMENT (this “Agreement”) dated as of September 26, 2008, between ISTA PHARMACEUTICALS, INC., a Delaware corporation (the “Debtor”), and the entities identified as secured parties on the signature page of this Agreement. (together, the “Secured Party”).

FACILITY AGREEMENT
Facility Agreement • September 30th, 2008 • Ista Pharmaceuticals Inc • In vitro & in vivo diagnostic substances • New York

FACILITY AGREEMENT (this “Agreement”), dated as of September 26, 2008 (the “Agreement Date”), between ISTA Pharmaceuticals, Inc., a Delaware corporation (the “Borrower”), and those lenders set forth on Schedule 1 attached hereto (individually, a “Lender” and together, the “Lenders” and, together with the Borrower, the “Parties”).

AMENDMENT
Amendment • September 30th, 2008 • Ista Pharmaceuticals Inc • In vitro & in vivo diagnostic substances

This AMENDMENT (the “Amendment”) is entered into as of September 26, 2008, by and between ISTA Pharmaceuticals, Inc., a Delaware corporation (the “Company”) and Highbridge International LLC (“Highbridge”).

LOAN MODIFICATION AGREEMENT
Loan Modification Agreement • September 30th, 2008 • Ista Pharmaceuticals Inc • In vitro & in vivo diagnostic substances

This Loan Modification Agreement (the “Agreement”) is entered into as of September 26, 2008, by and between ISTA PHARMACEUTICALS, INC., a Delaware corporation (the “Borrower”) and SILICON VALLEY BANK (“Bank”).

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