0001193125-07-173510 Sample Contracts

Convertible Promissory Note Amendment No. 1
Convertible Promissory • August 7th, 2007 • Cv Therapeutics Inc • Biological products, (no disgnostic substances)

This Convertible Promissory Note Amendment No. 1 (the “First Amendment to Note”) is entered into as of June 12, 2007 (the “Amendment Date”) by and between PTC Therapeutics, Inc., a Delaware corporation (“PTC”), and CV Therapeutics, Inc., a Delaware corporation (“CVT”), for the purpose of amending the Convertible Promissory Note between the same parties dated June 7, 2006 (hereinafter referred to as the “Convertible Note”), with reference to the following facts and circumstances.

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Contract
Collaboration and License Agreement • August 7th, 2007 • Cv Therapeutics Inc • Biological products, (no disgnostic substances)

This first amendment (“First Amendment”) to the Collaboration and License Agreement is entered into as of the 12th day of June, 2007, by and between CV Therapeutics, Inc. (“CVT”) and PTC Therapeutics, Inc. (“PTC”), with reference to the following facts and circumstances.

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