0001193125-07-077072 Sample Contracts

AGREEMENT ON COOPERATIVE RESEARCH AND DEVELOPMENT Institute of Bioorganic Chemistry, Polish Academy of Sciences (hereinafter referred to as “RESEARCHERS”) and Senetek PLC Napa, California 94558 USA (hereinafter referred to as “SENETEK”)
Agreement • April 9th, 2007 • Senetek PLC /Eng/ • Biological products, (no disgnostic substances)

WHEREAS the RESEARCHERS are performing basic research on Furfurylcytosine (the “Compounds”) and are willing to provide to SENETEK samples of the Compounds and their analogs and related information developed by the RESEARCHERS, including any covered by patents and/or patent applications owned by the RESEARCHERS, for testing, possible further development by SENETEK, and ultimately possible licensing to and commercialization by SENETEK; and

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Re: Payments in the Event of Certain Changes
Senetek PLC /Eng/ • April 9th, 2007 • Biological products, (no disgnostic substances)

In connection with your employment with Senetek Plc (the “Company”) the Board of Directors has agreed that you should have the benefit of certain protections in the event of certain changes of circumstance that are specifically described in this letter. Defined terms have the meaning ascribed to them in Section 4 of this letter agreement.

AMENDMENT
Amendment • April 9th, 2007 • Senetek PLC /Eng/ • Biological products, (no disgnostic substances)

This Amendment (this “Amendment”), dated as of May 19, 2006 (the “Effective Date”), is entered into by and among, Signet Laboratories, Inc., a Delaware corporation (“Signet”), Senetek Plc, a United Kingdom company (“Senetek”), Research Foundation for Mental Hygiene, Inc. (“RFMH”) and Covance Antibody Services, Inc., a California corporation (“Covance”).

CONTRACT FOR PERSONAL SERVICES
Contract for Personal Services • April 9th, 2007 • Senetek PLC /Eng/ • Biological products, (no disgnostic substances)

Effective August 1, 2006, Brian Clark is appointed Chief Scientist of Senetek PLC reporting to the Chairman and Chief Executive Officer of the Company.

AGREEMENT ON COOPERATIVE RESEARCH AND DEVELOPMENT between Institute of Bioorganic Chemistry, Polish Academy of Sciences (hereinafter referred to as “RESEARCHERS”) and Senetek PLC Napa, California 94558 USA (hereinafter referred to as “SENETEK”)
Agreement on Cooperative Research and Development • April 9th, 2007 • Senetek PLC /Eng/ • Biological products, (no disgnostic substances)

WHEREAS the RESEARCHERS are performing basic research on brain tumor treatment with interference RNA (iRNA—intervention with RNAi) (the “Treatment”) and are willing to provide to SENETEK information developed by the RESEARCHERS, including any covered by patents and/or patent applications owned by the RESEARCHERS, for possible licensing to and commercialization by SENETEK.

LICENSE AND INTELLECTUAL PROPERTY ACQUISITION AGREEMENT
License and Intellectual Property Acquisition Agreement • April 9th, 2007 • Senetek PLC /Eng/ • Biological products, (no disgnostic substances) • California

This License and Intellectual Property Acquisition Agreement (as amended from time to time, this “Agreement”), dated this 30th day of March, 2007, but effective as of January 1, 2007 (the “Effective Date”), is made by and between Senetek PLC, an English corporation (“Senetek”) and Valeant Pharmaceuticals North America, a Delaware corporation (“Valeant”).

AGREEMENT ON COOPERATIVE RESEARCH AND DEVELOPMENT between Institute of Bioorganic Chemistry, Polish Academy of Sciences (hereinafter referred to as “RESEARCHERS”) and Senetek PLC Napa, California 94558 USA (hereinafter referred to as “SENETEK”)
Senetek PLC /Eng/ • April 9th, 2007 • Biological products, (no disgnostic substances)

WHEREAS the RESEARCHERS, are performing basic research on phloretamide (the “Compounds”) and are willing to provide to SENETEK samples of the Compounds and their analogs and related information developed by the RESEARCHERS, including any covered by patents and/or patent applications owned by the RESEARCHERS, for testing, possible further development by SENETEK, and ultimately possible licensing to and commercialization by SENETEK; and

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