0001193125-06-220758 Sample Contracts

INDUSTRIAL LEASE (MULTI-TENANT; NET) BETWEEN THE IRVINE COMPANY ALSIUS CORPORATION INDEX TO LEASE
Industrial Lease • November 1st, 2006 • Ithaka Acquisition Corp • Blank checks • California

THIS LEASE is made as of the day of 16th day of March, 1999, by and between THE IRVINE COMPANY, hereafter called “Landlord,” and ALSIUS CORPORATION, a California corporation, hereinafter called “Tenant.”

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AMENDMENT NO. 3 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
Investor Rights Agreement • November 1st, 2006 • Ithaka Acquisition Corp • Blank checks • California

THIS AMENDMENT NO. 3 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (this “Amendment”), entered into on October 2, 2006, among ALSIUS CORPORATION, a California corporation (the “Company”), and the undersigned investors in the Company (the “Investors”).

AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
Investor Rights Agreement • November 1st, 2006 • Ithaka Acquisition Corp • Blank checks • California

THIS AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (this “Amendment”), entered into on April 13, 2006, among ALSIUS CORPORATION, a California corporation (the “Company”), and the undersigned investors in the Company (the “Investors”).

AMENDMENT NO. 2 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
Investor Rights Agreement • November 1st, 2006 • Ithaka Acquisition Corp • Blank checks • California

THIS AMENDMENT NO. 2 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (this “Amendment”), entered into on August 18, 2006, among ALSIUS CORPORATION, a California corporation (the “Company”), and the undersigned investors in the Company (the “Investors”).

Exclusive License Agreement between The Regents of the University of California and Alsius Corporation for Indwelling Heat Exchange Catheter Case No 99-501
Exclusive License Agreement • November 1st, 2006 • Ithaka Acquisition Corp • Blank checks • California

This license agreement (“Agreement”) is effective this — day of November 1999, by and between The Regents of the University of California (“The Regents”), a California corporation, having its statewide administrative offices at 1111 Franklin Street, 12th Floor, Oakland, California 94607-5200 acting through the offices of The University of California, Los Angeles located at 10945 Le Conte Avenue, Suite 1401, Los Angeles, California 90095-1406, and Alsius Corporation (“Licensee”), a California corporation, having a principal place of business at 15770 Laguna Canyon Road, Suite 150, Irvine, California 92618.

MASTER SECURITY AGREEMENT NO. 5051091 Dated as of May 31, 2005 (“AGREEMENT”)
Master Security Agreement • November 1st, 2006 • Ithaka Acquisition Corp • Blank checks • Virginia

THIS AGREEMENT is between OXFORD FINANCE CORPORATION (together with its successors and assigns, if any, “SECURED PARTY”) and Alsius Corporation (“DEBTOR”). Secured Party has an office at 133 N. Fairfax Street, Alexandria, VA 22314. Debtor is a corporation organized and existing under the laws of the state of California. Debtor’s mailing address and chief place of business is 15770 Laguna Canyon Road, Suite 150, Irvine, California 92618.

TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
Investor Rights Agreement • November 1st, 2006 • Ithaka Acquisition Corp • Blank checks • California

THIS TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (this “Agreement”), is entered into on September 2, 2004 among ALSIUS CORPORATION, a California corporation (the “Company”), and certain investors in the Company listed on Exhibit A hereto (as it may be amended from time to time pursuant to the terms hereof) (“Investors”).

NONEXCLUSIVE LICENSE AGREEMENT
Nonexclusive License Agreement • November 1st, 2006 • Ithaka Acquisition Corp • Blank checks • California

This Agreement is effective May 14, 1999, between Alsius Corporation with offices at #5 Jenner, Suite 150, Irvine, CA 92618-3808 (“ALSIUS”) and Baxter Healthcare Corporation, acting through its CardioVascular Group business unit with offices at 17211 Red Hill Avenue, Irvine, CA. 92614 (“BAXTER”).

ALSIUS CORPORATION CHANGE OF CONTROL AGREEMENT
Change of Control Agreement • November 1st, 2006 • Ithaka Acquisition Corp • Blank checks • California

THIS CHANGE OF CONTROL AGREEMENT (this “Agreement”), effective as of this 1st day of July, 2003 by and between (“Employee”) and ALSIUS CORPORATION, a California corporation (the “Company”).

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