0001193125-06-056571 Sample Contracts

DEVELOPMENT AGREEMENT
Development Agreement • March 16th, 2006 • Nanogen Inc • Laboratory analytical instruments • New Jersey

This Development Agreement (“Agreement”) is entered into as of this of December 2005 by and between PRINCETON BIOMEDITECH CORPORATION, a New Jersey Corporation (“PBM”), having its principal place of business at 4242 U.S. Route 1, Monmouth Junction, New Jersey 08852, and NANOGEN, INC., a Delaware Corporation (“NANOGEN”), having its principal place of business at 10398 Pacific Center Court, San Diego, California 92121.

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AMENDMENT NO. 2 TO SECOND AMENDED AND RESTATED COLLABORATION, LICENSE AND SUPPLY AGREEMENT
License and Supply Agreement • March 16th, 2006 • Nanogen Inc • Laboratory analytical instruments • California

THIS AMENDMENT NO. 2 TO SECOND AMENDED AND RESTATED COLLABORATION, LICENSE AND SUPPLY AGREEMENT (the “2nd Amendment”), is entered into as of December 31, 2005 (the “2nd Amendment Date”) by and between EPOCH BIOSCIENCES, INC., with offices at 21720 23rd Drive S.E., Suite 150, Bothell, WA ( “Epoch”), a wholly owned subsidiary of Nanogen, Inc., with offices at 10398 Pacific Center Ct., San Diego, CA 92121 (“Nanogen”); and APPLERA CORPORATION, through its Applied Biosystems group, with offices at 850 Lincoln Centre Drive, Foster City, CA 94404 (“ABG”). Each of Epoch and ABG is individually referred to as a “Party” and, collectively, as “Parties”.

MANUFACTURING AND DISTRIBUTION AGREEMENT
Manufacturing and Distribution Agreement • March 16th, 2006 • Nanogen Inc • Laboratory analytical instruments • New Jersey

This Manufacturing and Distribution Agreement (“Agreement”) is entered into as of this 27th of October, 2005 (the “Effective Date”) by and between PRINCETON BIOMEDITECH CORPORATION, a New Jersey Corporation (“PBM”), having its principal place of business at 4242 U.S. Route 1, Monmouth Junction, New Jersey 08852, and NANOGEN, INC., a Delaware Corporation (“NANOGEN”), having its principal place of business at 10398 Pacific Center Court, San Diego, California 92121.

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