0001193125-05-214442 Sample Contracts

7,400,000 Shares DURECT CORPORATION COMMON STOCK (PAR VALUE $0.0001 PER SHARE) UNDERWRITING AGREEMENT
Underwriting Agreement • November 2nd, 2005 • Durect Corp • Pharmaceutical preparations • New York

DURECT CORPORATION, a Delaware corporation (the “Company”), proposes to issue and sell to the several Underwriters named in Schedule II hereto (the “Underwriters”), and certain shareholders of the Company (the “Selling Shareholders”) named in Schedule I hereto severally propose to sell to the several Underwriters, an aggregate of 7,400,000 shares of the Common Stock (par value $0.0001 per share) of the Company (the “Firm Shares”), of which 7,367,744 shares are to be issued and sold by the Company and 32,256 shares are to be sold by the Selling Shareholders, each Selling Shareholder selling the amount set forth opposite such Selling Shareholder’s name under the heading “Firm Shares” in Schedule I hereto.

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