0001193125-04-108577 Sample Contracts

ORPHAN MEDICAL INC. AND CELLTECH PHARMACEUTICALS LTD. XYREM® LICENSE AND DISTRIBUTION AGREEMENT
License and Distribution Agreement • June 25th, 2004 • Celltech Group PLC • Pharmaceutical preparations • New York

This LICENSE AND DISTRIBUTION AGREEMENT (this “Agreement”) is made and entered into as of October 29, 2003 (“Effective Date”), by and between Orphan Medical, Inc., a corporation having its principal place of business at 13911 Ridgedale Drive, Suite 250, Minnetonka, Minnesota 55305, USA (together with its Affiliates, “Orphan Medical”), and Celltech Pharmaceuticals, Ltd., a biopharmaceutical company organized under the laws of England having its principal place of business at 208 Bath Road, Slough, Berkshire SL1 3WE, United Kingdom (together with its Affiliates, “Celltech”).

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Celltech Group PLC • June 25th, 2004 • Pharmaceutical preparations • England

*CONFIDENTIAL INFORMATION HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. REDACTED PORTIONS OF THIS EXHIBIT ARE MARKED BY AN *.

AMENDMENT TO OPTION AGREEMENT AND AGREEMENT
Option Agreement • June 25th, 2004 • Celltech Group PLC • Pharmaceutical preparations

This Amendment (this “Amendment”) to Option Agreement, dated July 23, 2002, between the parties hereto (the “Option Agreement”) and the Agreement, dated July 23, 2002, between the parties hereto (the “License Agreement”) is made as of April 15, 2004 (the “Date of this Amendment”) by and between Pfizer Health AB (formerly Pharmacia AB), a corporation organized and existing under the laws of Sweden (“Pfizer”), and Celltech Pharmaceuticals Ltd., a corporation organized and existing under the laws of England (“Celltech”).

MANUFACTURING SERVICES AGREEMENT dated: June 30, 2003 between CELLTECH R&D LIMITED and LONZA LIMITED
Manufacturing Services Agreement • June 25th, 2004 • Celltech Group PLC • Pharmaceutical preparations
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