0001193125-04-051033 Sample Contracts

SETTLEMENT AGREEMENT
Settlement Agreement • March 29th, 2004 • Orchid Biosciences Inc • In vitro & in vivo diagnostic substances • Missouri

This Settlement Agreement (“Agreement”) is entered into as of 6th day of August, 2002, by and between SAINT LOUIS UNIVERSITY, a non-profit organization organized and existing under the laws of the State of Missouri (“SLU”), and ORCHID BIOSCIENCES, INC., a Delaware Corporation (“ORCHID”).

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Contract
Assignment and License Agreement • March 29th, 2004 • Orchid Biosciences Inc • In vitro & in vivo diagnostic substances • California

ORCHID BIOSCIENCES, INC. HAS REQUESTED THAT THE MARKED PORTIONS OF THIS DOCUMENT BE ACCORDED 406 CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS AMENDED.

COMMERCIAL IN CONFIDENCE
Agreement • March 29th, 2004 • Orchid Biosciences Inc • In vitro & in vivo diagnostic substances • England and Wales

THIS AGREEMENT is made between Secretary of State for Environment, Food and Rural Affairs (“the Authority”) of Nobel House 17 Smith Square, London SW1P 3JR, and Orchid BioSciences Europe Limited (“the Contractor”) having its registered office at 22 Blacklands Way, Abingdon Business Park, Abingdon, Oxon, UK OX4 1DY. Together referred to as (“the Parties”).

AMENDMENT NO. 1 TO SETTLEMENT AGREEMENT
Settlement Agreement • March 29th, 2004 • Orchid Biosciences Inc • In vitro & in vivo diagnostic substances

This Amendment No. 1 to Settlement Agreement (this “Amendment”) is entered into as of October 1, 2003 (the “amendment Effective Date”) by and between Orchid BioSciences, Inc., a Delaware corporation having its principal office at 4390 U.S. Route 1 North, Princeton, NJ 08540 (“ORCHID), and Saint Louis University, a non-profit organization organized and existing under the laws of the State of Missouri (“SLU”). Capitalized terms used and not otherwise defined herein shall have the respective meanings ascribed to them in the Settlement Agreement by and between Orchid and SLU dated as of August 6, 2002 (the “Agreement”).

FIRST AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • March 29th, 2004 • Orchid Biosciences Inc • In vitro & in vivo diagnostic substances • Delaware

THIS FIRST AMENDMENT to that certain Employment Agreement, dated May 16, 2003, (the “Employment Agreement”) between Orchid BioSciences, Inc., a Delaware corporation (the “Company”), and Paul James Kelly (the “Employee”) is made effective as of November 3, 2003 (the “Effective Date”).

EXCLUSIVE PATENT LICENSE AGREEMENT
Exclusive Patent License Agreement • March 29th, 2004 • Orchid Biosciences Inc • In vitro & in vivo diagnostic substances • Missouri

This Exclusive Patent License Agreement (this “Agreement”) is made effective as of the Effective Date (as defined below) by and between Orchid BioSciences, Inc. (“ORCHID”), a Delaware corporation and Saint Louis University, a non-profit organization organized and existing under the laws of the State of Missouri (“SLU”). ORCHID and SLU are hereinafter referred to collectively as the “Parties.”

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