0001178670-22-000013 Sample Contracts

ALNYLAM PHARMACEUTICALS, INC. Performance Stock Unit Award Agreement Granted Under 2018 Stock Incentive Plan
Alnylam Pharmaceuticals, Inc. • February 10th, 2022 • Pharmaceutical preparations • Delaware

Pursuant to the Alnylam Pharmaceuticals, Inc. 2018 Stock Incentive Plan, as amended through the date hereof (the “Plan”), Alnylam Pharmaceuticals, Inc. (the “Company”) hereby grants an award of the number of Performance Stock Units listed above (this “Award”) to the Grantee named above on the Grant Date. Each Performance Stock Unit shall relate to one share of common stock, par value $0.01 per share (the “Stock”) of the Company. Unless earlier terminated, this Award shall have a term of ten (10) years from the Grant Date.

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ALNYLAM PHARMACEUTICALS, INC. Nonstatutory Stock Option Agreement Granted Under 2018 Stock Incentive Plan
Nonstatutory Stock Option Agreement • February 10th, 2022 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

Participant: [ ] ID: [ ] Award Number: [ ] Exercise Price Per Share: [ ] Grant Date: [ ] Vesting Commencement Date: [ ] Expiration Date: [ ] Number of Shares/Units: [ ]

Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed. AMENDMENT NO. 1 TO CO-DEVELOPMENT AGREEMENT
Co-Development Agreement • February 10th, 2022 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This AMENDMENT NO. 1 TO CO-DEVELOPMENT AGREEMENT (this “Amendment”) is entered into as of November 23, 2021 (the “Effective Date”), by and between Alnylam Pharmaceuticals, Inc., a Delaware corporation (“Alnylam”), BXLS V Bodyguard – PCP L.P., a Delaware limited partnership organized and existing under the laws of the state of Delaware, and BXLS Family Investment Partnership V – ESC L.P., a Delaware limited partnership organized and existing under the laws of the state of Delaware (collectively, “Blackstone”) (each, a “Party” and collectively, the “Parties”).

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