0001176256-06-000168 Sample Contracts

Angiotech Pharmaceuticals, Inc. REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • April 3rd, 2006 • Angiotech Pharmaceuticals Inc • Pharmaceutical preparations • New York

Angiotech Pharmaceuticals, Inc., a corporation organized under the laws of British Columbia (the “Issuer” or the “Company”), proposes to issue and sell to Credit Suisse Securities (USA) LLC and Merrill Lynch , Pierce, Fenner & Smith, Incorporated (collectively, the “Initial Purchasers”), upon the terms set forth in a purchase agreement dated March 16, 2006 (the “Purchase Agreement”), $250.0 million aggregate principal amount of its 7.75% Senior Subordinated Notes due 2014 (the “Initial Securities”) to be unconditionally guaranteed (the “Guarantees”) by the guarantors listed on the signature pages hereto (each a “Guarantor” and collectively the “Guarantors” and together with the Issuer, the “Company”). The Initial Securities will be issued pursuant to an Indenture, dated as of March 23, 2006 (the “Indenture”) among the Issuer, the Guarantors named therein and Wells Fargo Bank, N.A. (the “Trustee”). To induce the Initial Purchasers to enter the Purchase Agreement, the Company agrees with

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ANGIOTECH PHARMACEUTICALS, INC. AND EACH OF THE GUARANTORS PARTY HERETO 7.75 % SENIOR SUBORDINATED NOTES DUE 2014 INDENTURE Dated as of March 23, 2006 Wells Fargo Bank, N.A. Trustee
Supplemental Indenture • April 3rd, 2006 • Angiotech Pharmaceuticals Inc • Pharmaceutical preparations • New York

INDENTURE dated as of March 23, 2006 among Angiotech Pharmaceuticals, Inc., a corporation organized under the Business Corporations Act of the Province of British Columbia, the Guarantors (as defined) and Wells Fargo Bank, N.A., as trustee.

CREDIT AGREEMENT dated as of March 23, 2006 among ANGIOTECH PHARMACEUTICALS, INC., ANGIOTECH PHARMACEUTICALS (US), INC., as Borrowers, THE SUBSIDIARY GUARANTORS PARTY HERETO, as Guarantors THE LENDERS PARTY HERETO and CREDIT SUISSE, as Administrative...
Credit Agreement • April 3rd, 2006 • Angiotech Pharmaceuticals Inc • Pharmaceutical preparations • New York

CREDIT AGREEMENT dated as of March 23, 2006 (this “Agreement”), among ANGIOTECH PHARMACEUTICALS, INC., a corporation organized under the Business Corporations Act (British Columbia) (the “Term Borrower”), ANGIOTECH PHARMACEUTICALS (US), INC., a Washington corporation (the “Revolving Borrower,” and together with the Term Borrower, the “Borrowers” and each a “Borrower”), the SUBSIDIARY GUARANTORS party hereto (such term and each other term used but not defined herein have the meaning given to it in Article I), the LENDERS from time to time party hereto, CREDIT SUISSE, as administrative agent (in such capacity, the “Administrative Agent”) and as collateral agent (in such capacity, the “Collateral Agent”), CREDIT SUISSE SECURITIES (USA) LLC and MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED, as Joint Bookrunners and Joint Lead Arrangers (in such capacity, the “Arrangers” and each an “Arranger”), MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED, as syndication agent (in such capacity,

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