0001171843-16-009632 Sample Contracts

Fixed Dollar Accelerated Share Repurchase Transaction
Letter Agreement • May 3rd, 2016 • Anika Therapeutics, Inc. • Surgical & medical instruments & apparatus • New York

The purpose of this letter agreement (this “Confirmation”) is to confirm the terms and conditions of the Transaction entered into between Morgan Stanley & Co. LLC (“MSCO”) and Anika Therapeutics, Inc. (“Issuer”) on the Trade Date specified below (the “Transaction”). This confirmation constitutes a “Confirmation” as referred to in the Agreement specified below.

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AMENDMENT TO THE LEASE AGREEMENT (Reg.ne 39 series 3T) By and between
The Lease Agreement • May 3rd, 2016 • Anika Therapeutics, Inc. • Surgical & medical instruments & apparatus

FIDIA FARMACEUTICI S.P.A. with legal domicile in Abano Terme (PD) via Ponte della Fabbrica 3/A, Italy, VAT Code 00204260285 (hereinafter “Fidia”)

LEASE AMENDMENT AGREEMENT Between
Anika Therapeutics, Inc. • May 3rd, 2016 • Surgical & medical instruments & apparatus

on December 30, 2009, Fidia and FAB entered into a lease agreement (the "Agreement'') related to the lease of certain Property (as defined in the Agreement);

AMENDMENT TO THE LEASE AGREEMENT (Reg. 39 series 3T) Between
The Lease Agreement • May 3rd, 2016 • Anika Therapeutics, Inc. • Surgical & medical instruments & apparatus

On December 30, 2009, Fidia and Anika (formerly FAB S.r.l.) entered into a lease agreement (the “Agreement”), subsequently amended, regarding the lease of a certain Property (as defined in the Agreement)

LEASE AMENDMENT AGREEMENT Between
Agreement • May 3rd, 2016 • Anika Therapeutics, Inc. • Surgical & medical instruments & apparatus

on December 30, 2009, Fidia and FAB entered into a lease agreement (the "Agreement") related to the lease of certain Property (as defined in the Agreement);

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