0001157523-05-001630 Sample Contracts

9,575,000.00 December 31, 2004
Ariad Pharmaceuticals Inc • February 18th, 2005 • Biological products, (no disgnostic substances)

FOR VALUE RECEIVED, the undersigned, ARIAD PHARMACEUTICALS, INC., a Delaware corporation, ARIAD CORPORATION, a Delaware corporation, and ARIAD GENE THERAPEUTICS, INC., a Delaware corporation (hereinafter sometimes referred to collectively as the “Borrowers and each singly as a Borrower”), HEREBY UNCONDITIONALLY PROMISES TO PAY TO THE ORDER OF CITIZENS BANK OF MASSACHUSETTS, a Massachusetts bank (the “Lender”) at the office of the Lender, located at 28 State Street, Boston, Massachusetts 02109 (or such other place as the holder hereof may specify in writing), in lawful money of the United States of America and in immediately available funds, the principal amount of NINE MILLION FIVE HUNDRED SEVENTY-FIVE THOUSAND AND 00/100 DOLLARS ($9,575,000.00) (the “Loan”). The Borrowers jointly and severally agree to pay the principal amount of the Loan in the amounts and on the dates specified in subsection 2.5 of the Credit Agreement dated March 12, 2003, as amended by Amendment No. 1 to Credit Ag

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Credit Agreement • February 18th, 2005 • Ariad Pharmaceuticals Inc • Biological products, (no disgnostic substances) • Massachusetts

Exhibit 10.52 AMENDMENT NO. 2 TO CREDIT AGREEMENT THIS AMENDMENT NO. 2 (this “Amendment”) dated as of December 31, 2004 to the CREDIT AGREEMENT dated March 12, 2003, as amended by the Amendment No. 1 to Credit Agreement dated December 31, 2003 (collectively, the “Credit Agreement”), is by and among ARIAD Pharmaceuticals, Inc., a Delaware corporation, ARIAD Corporation, a Delaware corporation, and ARIAD Gene Therapeutics, Inc., a Delaware corporation (hereinafter sometimes referred to collectively as the “Borrowers”) and Citizens Bank of Massachusetts, a Massachusetts bank (the “Lender”). All capitalized terms not defined herein but defined in the Credit Agreement shall have the meanings given to such terms in the Credit Agreement. WHEREAS, the Borrowers and the Lender have agreed to certain modifications to the Credit Agreement as set forth herein. NOW, THEREFORE, in consideration of the mutual promises and covenants set forth herein, the Borrowers and the Lender hereby agree that the

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