0001140361-17-028398 Sample Contracts

LOAN AGREEMENT
Loan Agreement • July 21st, 2017 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS LOAN AGREEMENT, dated as of July 18, 2017 (as amended, restated, replaced, supplemented or otherwise modified from time to time, this “Agreement”), between UBS AG, by and through its branch office at 1285 Avenue of the Americas, New York, New York, having an address at 1285 Avenue of the Americas, 11th Floor, New York, New York 10019 (together with its successors and assigns, collectively, “Lender”), and IONIS FARADAY, LLC, a Delaware limited liability company having an address at 2855 Gazelle Court, Carlsbad, California 92010 (together with its permitted successors and assigns, collectively, “Borrower”).

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ENVIRONMENTAL INDEMNITY AGREEMENT
Environmental Indemnity Agreement • July 21st, 2017 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations • New York

ENVIRONMENTAL INDEMNITY AGREEMENT (this “Agreement”) made as of the 18th day of July, 2017 by IONIS GAZELLE, LLC a Delaware limited liability company, having an office at 2855 Gazelle Court, Carlsbad, California 92010 (“Borrower”), and IONIS PHARMACEUTICALS, INC., a Delaware corporation, having an office at 2855 Gazelle Court, Carlsbad, California 92010 (“Guarantor”, and together with Borrower, “Indemnitor”), in favor of UBS AG, by and through its branch office at 1285 Avenue of the Americas, New York, New York, having an address at 1285 Avenue of the Americas, 11th Floor, New York, New York 10019 (“Indemnitee”) and other Indemnified Parties (defined below).

GUARANTY
Guaranty • July 21st, 2017 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations • New York

This GUARANTY (this “Guaranty”) is executed as of July 18, 2017 by IONIS PHARMACEUTICALS, INC., a Delaware corporation, having an address at 2855 Gazelle Court, Carlsbad, California 92010 (whether one or more collectively referred to as “Guarantor”), for the benefit of UBS AG, by and through its branch office at 1285 Avenue of the Americas, New York, New York, having an address at 1285 Avenue of the Americas, 11th Floor, New York, New York 10019 (together with its successors and assigns, “Lender”).

LOAN AGREEMENT
Loan Agreement • July 21st, 2017 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS LOAN AGREEMENT, dated as of July 18, 2017 (as amended, restated, replaced, supplemented or otherwise modified from time to time, this “Agreement”), between UBS AG, by and through its branch office at 1285 Avenue of the Americas, New York, New York, having an address at 1285 Avenue of the Americas, 11th Floor, New York, New York 10019 (together with its successors and assigns, collectively, “Lender”), and IONIS GAZELLE, LLC, a Delaware limited liability company having an address at 2855 Gazelle Court, Carlsbad, California 92010 (together with its permitted successors and assigns, collectively, “Borrower”).

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