0001113481-16-000058 Sample Contracts

SECOND AMENDMENT TO CHEMILOG DEVELOPMENT AND SUPPLY AGREEMENT
Chemilog Development and Supply Agreement • February 29th, 2016 • Medicines Co /De • Pharmaceutical preparations

This SECOND AMENDMENT TO CHEMILOG DEVELOPMENT AND SUPPLY AGREEMENT, made as of the 11th day of June, 2015, between LONZA SALES LTD ("LONZA") and THE MEDICINES COMPANY ("MDCO").

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AMENDMENT TO CONTRACT MANUFACTURING AGREEMENT
Contract Manufacturing Agreement • February 29th, 2016 • Medicines Co /De • Pharmaceutical preparations

THIS AMENDMENT (“Amendment”) is made and entered into this 20th day of February, 2013 (“Amendment Effective Date”) by and between Fresenius Kabi USA, LLC (successor in interest to APP Pharmaceuticals, LLC) (“Fresenius”) and The Medicines Company (“MDCO”).

FIRST AMENDMENT TO CHEMILOG DEVELOPMENT AND SUPPLY AGREEMENT
Chemilog Development and Supply Agreement • February 29th, 2016 • Medicines Co /De • Pharmaceutical preparations

This FIRST AMENDMENT TO CHEMILOG DEVELOPMENT AND SUPPLY AGREEMENT, made as of the _1 day of August, 2005, between UCB-BIOPRODUCTS S.A., now UCB S.A (“UCB”) and THE MEDICINES COMPANY (“TMC”).

NAME] [ADDRESS] [ADDRESS] [DATE] Dear [ ],
Medicines Co /De • February 29th, 2016 • Pharmaceutical preparations

This letter amends the letter agreement regarding severance between you and The Medicines Company (the “Company”), dated «Most_Recent_Agreement_Date» (the “Agreement”). Unless otherwise expressly set forth herein, the terms of the Agreement remain unchanged and in full force and effect.

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