0001113481-15-000011 Sample Contracts

THIRD AMENDMENT TO THE CONSULTING AGREEMENT
The Consulting Agreement • March 2nd, 2015 • Medicines Co /De • Pharmaceutical preparations

THIS Third Amendment (the “Amendment”) to the Consulting Agreement is effective as of July 7, 2014 (the “Amendment Effective Date”), by and between THE MEDICINES COMPANY, a Delaware corporation with its principal place of business located at 8 Sylvan Way, Parsippany, New Jersey 07054 (the “Company”) and STRATEGIC IMAGERY, LLC, having an address of 2604 North Greenway Drive, Coral Gables, Florida 33134 (“the Consultant”). The Company and Consultant may at times throughout this Amendment be referred to individually as a “Party” and collectively as the “Parties”.

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SECOND AMENDMENT TO THE CONSULTING AGREEMENT
The Consulting Agreement • March 2nd, 2015 • Medicines Co /De • Pharmaceutical preparations

This Second Amendment (the "Amendment") to the Consulting Agreement is effective as of July 6, 2013 (the "Amendment Effective Date"), by and between THE MEDICINES COMPANY, a De1aware corporation with its principal place of business located at 8 Sylvan Way, Parsippany, New Jersey 07054 (the "Company") and STRATEGIC IMAGERY, LLC, having an address of 315 South Shore Drive, Sarasota, Florida 34234 (the "Consultant"). The Company and the Consultant shall, at times throughout this Amendment, be referred to individually as a "Party" and collectively as the "Parties".

SETTLEMENT AND AMENDMENT TO MERGER AGREEMENT
Settlement and Amendment to Merger Agreement • March 2nd, 2015 • Medicines Co /De • Pharmaceutical preparations

This Settlement and Amendment to Merger Agreement (this “Agreement”), dated as of December 8, 2014 is made by and between THE MEDICINES COMPANY, a Delaware corporation (the “Buyer”) and FORTIS ADVISORS LLC, a Delaware limited liability company, solely in its capacity as the Representative (the “Representative”) of the Company Equityholders of Incline Therapeutics, Inc., a Delaware corporation (the “Company”) pursuant to the terms of that certain Agreement and Plan of Merger dated December 11, 2012 (the “Merger Agreement”) by and among the Buyer, the Company, the Representative and Silver Surfer Acquisition Corp., a Delaware corporation and a wholly owned subsidiary of the Buyer. Capitalized terms used herein and not defined herein shall have the meaning given to them in the Merger Agreement.

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