0001113481-12-000036 Sample Contracts

SEVERANCE AGREEMENT AND FULL AND FINAL MUTUAL GENERAL RELEASE OF CLAIMS
Severance Agreement • August 9th, 2012 • Medicines Co /De • Pharmaceutical preparations

This Severance Agreement and Full and Final Mutual General Release of Claims (“Agreement”) is made and entered into by and between LESLIE C. ROHRBACKER (“ROHRBACKER”) and THE MEDICINES COMPANY (“MDCO”).

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GLOBAL COLLABORATION AGREEMENT by and between ASTRAZENECA LP and THE MEDICINES COMPANY Dated as of April 25, 2012
Global Collaboration Agreement • August 9th, 2012 • Medicines Co /De • Pharmaceutical preparations • Delaware
THIRD AMENDMENT TO SECOND AMENDED AND RESTATED DISTRIBUTION AGREEMENT
Distribution Agreement • August 9th, 2012 • Medicines Co /De • Pharmaceutical preparations

This Third Amendment to Second Amended and Restated Distribution Agreement (this “Amendment”) is between The Medicines Company, a Delaware corporation with offices at 8 Sylvan Way, Parsippany, NJ 07054 (“MDCO”), and Integrated Commercialization Solutions, Inc., a California corporation with offices at 3101 Gaylord Parkway, Frisco, TX 75034 (“Distributor”). This Amendment is effective as of April 23, 2012 (the “Amendment Effective Date”). MDCO and Distributor shall, at times throughout this Amendment, be referred to individually as a “Party” and collectively as the “Parties”.

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