0001113481-11-000027 Sample Contracts

LICENSE AGREEMENT BY AND AMONG THE MEDICINES COMPANY AND TEVA PHARMACEUTICALS USA, INC. DATED AS OF SEPTEMBER 30, 2011
License Agreement • November 9th, 2011 • Medicines Co /De • Pharmaceutical preparations • New York

THIS LICENSE AGREEMENT (this “Agreement”) is entered into as of September 30, 2011 (the “Effective Date”) by and between The Medicines Company, a company organized and existing under the laws of the State of Delaware with offices located at 8 Sylvan Way, Parsippany, New Jersey 07054 and its Affiliates (collectively, “MDCO”), and Teva Pharmaceuticals USA, Inc., a corporation organized and existing under the laws of the State of Delaware with offices located at 1090 Horsham Road, North Wales, Pennsylvania 19454 and its Affiliates (collectively “Teva”). Each of MDCO and Teva is sometimes referred to herein, individually, as a “Party” and, collectively, as the “Parties.”

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SETTLEMENT AGREEMENT BY AND AMONG THE MEDICINES COMPANY AND TEVA PHARMACEUTICALS USA, INC. DATED AS OF SEPTEMBER 30, 2011
Settlement Agreement • November 9th, 2011 • Medicines Co /De • Pharmaceutical preparations • New York

THIS SETTLEMENT AGREEMENT, (this “Settlement Agreement”) is entered into as of September 30, 2011 (the “Effective Date”) by and between The Medicines Company, a company organized and existing under the laws of the State of Delaware with offices located at 8 Sylvan Way, Parsippany, New Jersey 07054 and its Affiliates (collectively “MDCO”), and Teva Pharmaceuticals USA, Inc., a corporation organized and existing under the laws of the State of Delaware with offices located at 1090 Horsham Road, North Wales, Pennsylvania 19454 and its Affiliates (collectively “Teva”). Each of MDCO and Teva is sometimes referred to herein, individually, as a “Party” and, collectively, as the “Parties.”

SUPPLY AGREEMENT
Supply Agreement • November 9th, 2011 • Medicines Co /De • Pharmaceutical preparations • New York

WHEREAS, Plantex is a manufacturer (through its Affiliates) of active pharmaceutical ingredients at Plantex’s Facility, as defined below,

SECOND AMENDMENT TO SECOND AMENDED AND RESTATED DISTRIBUTION AGREEMENT
Distribution Agreement • November 9th, 2011 • Medicines Co /De • Pharmaceutical preparations

This Second Amendment to Second Amended and Restated Distribution Agreement (this “Amendment”) is between The Medicines Company, a Delaware corporation with offices at 8 Sylvan Way, Parsippany, NJ 07054 (“MDCO”), and Integrated Commercialization Solutions, Inc., a California corporation with offices at 3101 Gaylord Parkway, Frisco, TX 75034 (“Distributor”). This Amendment is effective as of September 1, 2011 (the “Amendment Effective Date”). MDCO and Distributor shall, at times throughout this Amendment, be referred to individually as a “Party” and collectively as the “Parties”.

Manufacturing Services Agreement March 30, 2011
Manufacturing Services Agreement • November 9th, 2011 • Medicines Co /De • Pharmaceutical preparations • Delaware

Lindenstrasse 14, 6340 Baar, (Switzerland) a corporation existing under the laws of Switzerland, (hereinafter referred to as “Patheon”),

FIRST AMENDMENT TO SECOND AMENDED AND RESTATED DISTRIBUTION AGREEMENT
Distribution Agreement • November 9th, 2011 • Medicines Co /De • Pharmaceutical preparations

This First Amendment to Second Amended and Restated Distribution Agreement (this “Amendment”) is between The Medicines Company, a Delaware corporation with offices at 8 Sylvan Way, Parsippany, NJ 07054 (“MDCO”), and Integrated Commercialization Solutions, Inc., a California corporation with offices at 3101 Gaylord Parkway, Frisco, TX 75034 (the “Distributor”). This Amendment is effective as of July 1, 2011 (the “Amendment Effective Date”).

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