0001104659-23-087375 Sample Contracts

August 3, 2023 Hunter Smith Dear Hunter:
Rhythm Pharmaceuticals, Inc. • August 3rd, 2023 • Pharmaceutical preparations

On behalf of Rhythm Pharmaceuticals, Inc. (the “Company”), I am pleased to set forth below the updated terms of your employment with the Company. You and the Company previously were parties to the second amended and restated employment offer letter, dated December 21, 2017 (the “Prior Letter”). This letter agreement amends and supersedes the Prior Letter in its entirety.

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