0001104659-23-080764 Sample Contracts

Bicycle Therapeutics plc 4,705,884 American Depositary Shares representing 4,705,884 Ordinary Shares, nominal value £0.01 per share 4,705,882 Non-Voting Ordinary Shares, nominal value £0.01 per share Underwriting Agreement
Underwriting Agreement • July 13th, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations

The ADSs are to be issued pursuant to a deposit agreement (the “Deposit Agreement”), dated as of May 28, 2019, among the Company, Citibank, N.A., as depositary (the “Depositary”), and the holders and beneficial owners from time to time of the American Depositary Receipts (the “ADRs”) issued thereunder by the Depositary and evidencing the ADSs. Each ADS will initially represent the right to receive one Ordinary Share with a nominal value of £0.01 per share, deposited pursuant to the Deposit Agreement.

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