0001104659-23-011530 Sample Contracts

OPEN MARKET SALE AGREEMENTSM
Open Market Sale • February 7th, 2023 • Praxis Precision Medicines, Inc. • Pharmaceutical preparations • New York

Praxis Precision Medicines, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”), shares of the Company’s common stock, par value $0.0001 per share (the “Common Shares”), having an aggregate offering price of up to $125 million on the terms set forth in this agreement (this “Agreement”).

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