0001104659-21-071220 Sample Contracts

AKREVIA THERAPEUTICS INC. AKREVIA CONCERTO LLC LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • May 24th, 2021 • Xilio Therapeutics, Inc. • Pharmaceutical preparations • North Carolina

This LOAN AND SECURITY AGREEMENT (the “Agreement”) is entered into as of November 21, 2019, by and between PACIFIC WESTERN BANK, a California state chartered bank (“Bank”), and Akrevia Therapeutics Inc. and Akrevia Concerto LLC (individually and collectively referred to as “Borrower”).

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Xilio Therapeutics, Inc. Restricted Stock Agreement Granted Under 2020 Stock Incentive Plan
Restricted Stock Agreement • May 24th, 2021 • Xilio Therapeutics, Inc. • Pharmaceutical preparations • Delaware

This Restricted Stock Agreement (the “Agreement”) is made this [____] day of [_____________], 20[ ], between Xilio Therapeutics, Inc., a Delaware corporation (the “Company”), and [________________________] (the “Participant”).

Xilio Therapeutics, Inc. Stock Option Agreement Granted Under 2020 Stock Incentive Plan
Stock Option Agreement • May 24th, 2021 • Xilio Therapeutics, Inc. • Pharmaceutical preparations

This Stock Option Agreement (this “Agreement”) is made between Xilio Therapeutics, Inc., a Delaware corporation (the “Company”), and the Participant pursuant to the 2020 Stock Incentive Plan (the “Plan”).

Re: Employment Agreement
Xilio Therapeutics, Inc. • May 24th, 2021 • Pharmaceutical preparations • Massachusetts

On behalf of Akrevia Therapeutics Inc. (the “Company”), I am pleased to offer you the position as the Company’s Chief Operating Officer (“COO”). The terms of your employment are set forth below in this Employment Agreement (the “Agreement.)

SERVICE AGREEMENT
Service Agreement • May 24th, 2021 • Xilio Therapeutics, Inc. • Pharmaceutical preparations • Massachusetts

THIS SERVICE AGREEMENT (this “Agreement”), made this 11th day of June, 2020, is entered into by Xilio Therapeutics Inc., a Delaware corporation (the “Company”), and Daniel S. Lynch (the “Director”).

VIA ELECTRONIC MAIL March 12, 2021 Joseph L. Farmer Dear Joe:
Consulting Agreement • May 24th, 2021 • Xilio Therapeutics, Inc. • Pharmaceutical preparations • Massachusetts

As we discussed, your employment with Xilio Therapeutics, Inc. (f/k/a/ Akrevia Therapeutics, Inc., and hereinafter, the “Company”) will end effective March 12, 2021 (the “Separation Date”). As we also discussed, although you are electing to leave the Company, the Company has agreed to provide you with the severance benefits described in detail in paragraph 1 below if you sign and return this letter agreement to me no later than April 3, 2021 (but no earlier than the Separation Date) and do not revoke your agreement (as described below). By signing and returning this letter agreement and not revoking your acceptance, you will be entering into a binding agreement with the Company and will be agreeing to the terms and conditions set forth in the numbered paragraphs below, including the release of claims set forth in paragraph 2. Therefore, you are advised to consult with an attorney before signing this letter agreement and you have been given at least twenty-one (21) days to do so. If you

CTLA-4 MONOCLONAL ANTIBODY LICENSE AGREEMENT
License Agreement • May 24th, 2021 • Xilio Therapeutics, Inc. • Pharmaceutical preparations • Delaware

In consideration of the mutual promises and conditions set forth herein and other good and valuable consideration, WuXi and Akriveia, intending to be legally bound, agree as follows:

Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) is the type of information that the registrant treats as private or confidential. Double asterisks denote omissions. AMENDED AND RESTATED...
Exclusive License Agreement • May 24th, 2021 • Xilio Therapeutics, Inc. • Pharmaceutical preparations • California

THIS AMENDED AND RESTATED EXCLUSIVE LICENSE AGREEMENT (this “Agreement”) is made and entered into as of the 16th day of August, 2016 (the “Effective Date”) by and between Akriveia Therapeutics Inc., a for-profit company with a registered address at 615 South DuPont Highway, Dover, DE 19901 (“Licensee”) and City of Hope, a California nonprofit public benefit corporation located at 1500 East Duarte Road, Duarte, California 91010 (“City of Hope” or “COH”). Licensee and COH are each sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

CROSS-LICENSE AGREEMENT
Cross-License Agreement • May 24th, 2021 • Xilio Therapeutics, Inc. • Pharmaceutical preparations • Delaware

This Cross-License Agreement (“Agreement”), effective as of December 16, 2020 (the “Effective Date”) and executed on February 11, 2021 (the “Execution Date”), is by and among Xilio Development, Inc., a Delaware corporation with an address at 828 Winter Street, Waltham, MA 02451 (“Xilio”), AskGene Pharma, Inc., a Delaware corporation with an address at 5217 Verdugo Way, Suite A, Camarillo, CA 93012 (“AskGene”) and, solely for purposes of Section 12.8, Xilio Therapeutics, Inc., a Delaware corporation with an address at 828 Winter Street, Waltham, MA 02451 (“Parent”). Xilio and AskGene are referred to herein collectively as the “Parties” and each individually as a “Party.”

XILIO THERAPEUTICS, INC. AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT FEBRUARY 23, 2021 AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • May 24th, 2021 • Xilio Therapeutics, Inc. • Pharmaceutical preparations • Delaware

THIS AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made as of the 23rd day of February, 2021, by and among Xilio Therapeutics, Inc., a Delaware corporation (the “Company”), each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an “Investor,” and any person that becomes a party to this Agreement in accordance with Section 3.9 hereof.

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