0001104659-12-069434 Sample Contracts

AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER

Agreement and Plan of Merger • October 16th, 2012 • Synergy Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

• Contract Type
  Agreement and Plan of Merger
• Filed
  October 16th, 2012
• Company
  Synergy Pharmaceuticals, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

THIS AMENDMENT NO. 1 TO THE AGREEMENT AND PLAN OF MERGER (this “Amendment”), dated as of October 15, 2012, is made by and among Synergy Pharmaceuticals Inc., a Delaware corporation (“Synergy”) and Callisto Pharmaceuticals, Inc., a Delaware corporation (“Callisto”).