0001104659-09-055824 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • September 23rd, 2009 • Helicos Biosciences Corp • Pharmaceutical preparations

This Registration Rights Agreement (this “Agreement”) is made and entered into as of September 15, 2009, by and among Helicos BioSciences Corporation, a Delaware corporation (the “Company”), and the several purchasers signatory hereto (each a “Purchaser” and collectively, the “Purchasers”).

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JOINT FILING AGREEMENT
Joint Filing Agreement • September 23rd, 2009 • Helicos Biosciences Corp • Pharmaceutical preparations

Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, each of the undersigned hereby agrees that this Amendment No. 1 to Schedule 13D is filed on behalf of each of them. This Agreement may be executed in any number of counterparts, each of which shall be deemed an original.

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