February 1, 2007 VIA HAND DELIVERY Jeffrey M. Jonas, M.D. Executive Vice President Isis Pharmaceuticals, Inc. 1896 Rutherford Road Carlsbad, CA 92008 Dear Jeff:Separation Agreement • February 7th, 2007 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • California
Isis Pharmaceuticals, Inc. (“Isis”) is pleased to offer you certain severance benefits in light of your future contribution to Isis. As Isis has no policy or procedure requiring such benefits, we request that you keep the terms and conditions of this letter agreement confidential.
