0001104659-06-044965 Sample Contracts

AMENDMENT TO RESEARCH AND LICENSE AGREEMENT
Research and License Agreement • June 30th, 2006 • Combinatorx, Inc • Pharmaceutical preparations • New York

This Amendment, dated as of June 26, 2006 (the “Amendment”) between Fovea Pharmaceuticals SA, a company organized and existing under the laws of France, with an office at 3-5 Impasse Reille, 75014 Paris, France (“Fovea”) and CombinatoRx, Incorporated, a company organized and existing under the laws of Delaware, with an office at 245 First Street, Sixteenth Floor, Cambridge, MA 02142 (“CombinatoRx”) amends the Research and License Agreement (the “Agreement”), dated as of January 30, 2006, between Fovea and CombinatoRx. Each of Fovea and CombinatoRx are sometimes referred to herein as a “Party” and together as the “Parties.” Unless otherwise changed by this Amendment, capitalized terms shall have the meaning provided in the Agreement.

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