SECOND AMENDED AND RESTATED COLLABORATION AGREEMENT BETWEEN ELI LILLY AND COMPANY AND ISIS PHARMACEUTICALS, INC. August 5, 2005Collaboration Agreement • November 9th, 2005 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York
THIS SECOND AMENDED AND RESTATED COLLABORATION AGREEMENT (the “Agreement”) executed on August 5, 2005 (the “Second Restatement Execution Date”) and effective as of August 25, 2005 (the “Second Restatement Date”), by and between ELI LILLY AND COMPANY, a corporation organized and existing under the laws of Indiana and its Affiliates (together “Lilly”), and ISIS PHARMACEUTICALS, INC., a corporation organized and existing under the laws of Delaware (“Isis”).
RESTATED ISIS PHARMACEUTICALS, INC. 10B5-1 TRADING PLANTrading Plan • November 9th, 2005 • Isis Pharmaceuticals Inc • Pharmaceutical preparations
This 10b5-1 Trading Plan, (the “Trading Plan”), between ISIS PHARMACEUTICALS, INC. (“Isis”) and HORWITZ & ASSOCIATES, INC (“Broker”), is entered into effective September 30, 2005 (the “Effective Date”). Capitalized terms not otherwise defined herein will have the meanings given to them in Exhibit A attached hereto.
SUBCONTRACT AGREEMENT Time and Material / Labor HourSubcontract Agreement • November 9th, 2005 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
This Subcontract Agreement, effective [ ] is made between SCIENCE APPLICATIONS INTERNATIONAL CORPORATION (hereinafter known as “Buyer”), a Delaware corporation with principal offices in San Diego, California, and Isis Pharmaceuticals, Inc. (hereinafter known as “Seller”), a corporation, with principal offices in Carlsbad, California. The effort to be performed by Seller under this Subcontract will be part of Buyer’s Prime Contract # [ ] that has been issued by [ ]. The work, defined in Attachment I (Statement of Work and Schedule) will be performed on a Time and Material/Labor Hour basis, in accordance with Schedule A (Specific Terms and Conditions), and any referenced document in 18.0 Order of Precedence clause of this agreement.
