0001104659-02-006320 Sample Contracts

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. COMMERCIAL SUPPLY AND PROCESS VALIDATION AGREEMENT
Supply and Process Validation Agreement • November 15th, 2002 • Transkaryotic Therapies Inc • Biological products, (no disgnostic substances) • Maryland

THIS COMMERCIAL SUPPLY AGREEMENT (the “Agreement”) is entered into as of this 6th day of December, 1999 by and between TRANSKARYOTIC THERAPIES, INC.,(“TKT”), a Delaware corporation having an address at 195 Albany Street, Cambridge, MA 02139, and CHESAPEAKE BIOLOGICAL LABORATORIES, INC., a Maryland corporation having an address at 1111 South Paca Street, Baltimore, MD 21230 (“CBL”), with respect to the following:

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MASTER PRODUCTION AGREEMENT
Master Production Agreement • November 15th, 2002 • Transkaryotic Therapies Inc • Biological products, (no disgnostic substances) • Maryland

This Master Production Agreement (this “Agreement”) is made as of this 1st day of December, 1998 between Bio Science Contract Production Corp., a Maryland corporation (“BSCP”), and Transkaryotic Therapies Inc, a Delaware corporation (“Client”).

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