0001062822-09-000119 Sample Contracts

19,894,076 Shares LEXICON PHARMACEUTICALS, INC. COMMON STOCK, PAR VALUE $0.001 PER SHARE UNDERWRITING AGREEMENT

Underwriting Agreement • October 9th, 2009 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • New York

• Contract Type
  Underwriting Agreement
• Filed
  October 9th, 2009
• Company
  Lexicon Pharmaceuticals, Inc./De
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

The undersigned understands that Morgan Stanley & Co. Incorporated (“Morgan Stanley”) proposes to enter into an Underwriting Agreement (the “Underwriting Agreement”) with Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”), providing for the public offering (the “Public Offering”) by the several Underwriters, including Morgan Stanley (the “Underwriters”), of shares (the “Shares”) of the common stock, par value $0.001 per share, of the Company (the “Common Stock”).

PURCHASE AGREEMENT

Purchase Agreement • October 9th, 2009 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations

• Contract Type
  Purchase Agreement
• Filed
  October 9th, 2009
• Company
  Lexicon Pharmaceuticals, Inc./De
• Industry
  Pharmaceutical preparations