0001047469-09-002309 Sample Contracts

COLLABORATIVE RESEARCH, DEVELOPMENT AND LICENSE AGREEMENT between ARQULE, INC. and DAIICHI SANKYO CO., LTD November 7, 2008
And License Agreement • March 6th, 2009 • Arqule Inc • Pharmaceutical preparations • Massachusetts

This COLLABORATIVE RESEARCH DEVELOPMENT AND LICENSE AGREEMENT (this “Agreement”) is entered into as of November 7, 2008, by and between ARQULE, Inc., a Delaware corporation with offices at 19 Presidential Way, Woburn, MA 01801-5140 (“ARQULE”), and Daiichi Sankyo Co., Ltd, a Japanese company organized under the laws of Japan with offices at 3-5-1 Nihonbashi Honcho, Chuo-ku, Tokyo 103-8426, Japan (“DS”). Each of DS and ARQULE is sometimes referred to individually herein as a “Party” and collectively as the “Parties.”

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LICENSE, CO-DEVELOPMENT AND CO-COMMERCIALIZATION AGREEMENT BY AND BETWEEN ARQULE, INC. and DAIICHI SANKYO CO., LTD December 18, 2008
Commercialization Agreement • March 6th, 2009 • Arqule Inc • Pharmaceutical preparations • Massachusetts

This LICENSE, CO-DEVELOPMENT AND CO-COMMERCIALIZATION AGREEMENT (this “Agreement”) is entered into as of December 18, 2008 (the “Execution Date”) and effective as of the Effective Date (as defined below), by and between ArQule, Inc., a Delaware corporation with offices at 19 Presidential Way, Woburn, Massachusetts 01801 (“ARQULE”), and Daiichi Sankyo Co., Ltd, a Japanese company organized under the laws of Japan with offices at 3-5-1 Nihonbashi Honcho, Chuo-ku, Tokyo 103-8426, Japan (“DS”). Each of DS and ARQULE is sometimes referred to individually herein as a “Party” and collectively as the “Parties.”

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