0001047469-08-004573 Sample Contracts

AMENDMENT TO LETTER AGREEMENT
Letter Agreement • April 11th, 2008 • Millennium Pharmaceuticals Inc • Pharmaceutical preparations

WHEREAS, Millennium Pharmaceuticals, Inc. (the “Company”) and Marsha H. Fanucci (the “Employee”) are parties to a certain Letter Agreement dated as of August 6, 2004 (the “Letter Agreement”);

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AGREEMENT AND PLAN OF MERGER DATED AS OF APRIL 10, 2008 AMONG TAKEDA AMERICA HOLDINGS, INC., MAHOGANY ACQUISITION CORP. AND MILLENNIUM PHARMACEUTICALS, INC.
Agreement and Plan of Merger • April 11th, 2008 • Millennium Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

Agreement and Plan of Merger (this "Agreement"), dated as of April 10, 2008, among Takeda America Holdings, Inc., a New York corporation ("Parent"), Mahogany Acquisition Corp., a Delaware corporation and wholly-owned subsidiary of Parent ("Merger Sub"), and Millennium Pharmaceuticals, Inc., a Delaware corporation (the "Company").

AMENDMENT TO LETTER AGREEMENT
Letter Agreement • April 11th, 2008 • Millennium Pharmaceuticals Inc • Pharmaceutical preparations

WHEREAS, Millennium Pharmaceuticals, Inc. (the “Company”) and Deborah Dunsire (the “Employee”) are parties to a certain Letter Agreement dated as of June 21, 2005 (the “Letter Agreement”);

TENDER AND SUPPORT AGREEMENT
Tender and Support Agreement • April 11th, 2008 • Millennium Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

This TENDER AND SUPPORT AGREEMENT (this "Agreement"), is dated as of April 10, 2008, by and between TAKEDA AMERICA HOLDINGS, INC., a New York corporation (the "Parent"), and the stockholders listed on the signature pages hereto (each a "Stockholder" and collectively, the "Stockholders").

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