0001047469-05-016932 Sample Contracts

GENTIUM S.p.A. and THE BANK OF NEW YORK As Depositary and OWNERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY RECEIPTS Deposit Agreement Dated as of , 2005
Deposit Agreement • June 9th, 2005 • Gentium S.p.A. • Pharmaceutical preparations • New York

DEPOSIT AGREEMENT dated as of , 2005 among GENTIUM S.p.A., incorporated under the laws of the Republic of Italy (herein called the Company), THE BANK OF NEW YORK, a New York banking corporation (herein called the Depositary), and all Owners and Beneficial Owners from time to time of American Depositary Receipts issued hereunder.

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UNDERWRITING AGREEMENT Among GENTIUM, S.p.A., MAXIM GROUP LLC And I-BANKERS SECURITIES INCORPORATED Dated: June , 2005
Gentium S.p.A. • June 9th, 2005 • Pharmaceutical preparations • New York

Maxim Group LLC I-Bankers Securities Incorporated As Representatives of the Several Underwriters c/o Maxim Group LLC 405 Lexington Avenue, 2nd Floor New York, New York 10174

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