EXHIBIT 10.10 11099 North Torrey Pines Road La Jolla, CA 92037 EXPANSION LEASE BY AND BETWEEN Health Science Properties, Inc. and Sequana Therapeutics, Inc. TABLE OF CONTENTSLetter Agreement • March 29th, 2004 • Senomyx Inc • Services-commercial physical & biological research • California
August 25, 2003 Harry Leonhardt PO Box 3023 Rancho Santa Fe CA 92067 Dear Harry:Senomyx Inc • March 29th, 2004 • Services-commercial physical & biological research • California
We are pleased to extend to you an offer to join Senomyx, Inc. ("Company") as our Vice President and General Counsel. The following terms apply and will constitute your employment agreement with the Company (the "Agreement").
QuickLinks -- Click here to rapidly navigate through this documentSenomyx Inc • March 29th, 2004 • Services-commercial physical & biological research • California
We are pleased to extend to you an offer to join Senomyx, Inc. ("Company") as our President and Chief Executive Officer. The following terms apply and will constitute your employment agreement with the Company (the "Agreement").
SENOMYX LOGO] 11099 N. Torrey Pines Road, Suite 160 La Jolla, CA 92037 Telephone: 858-646-8300 Facsimile: 858-404-0750 June 7, 2000 Klaus Gubernator 13434 Glencliff Way San Diego, CA 92130 Telephone: (858) 350-8341 Dear Klaus:Senomyx Inc • March 29th, 2004 • Services-commercial physical & biological research
It is my pleasure to provide you with this letter setting forth the principal terms for you to join Senomyx, Inc., a Delaware corporation (the "Company"), which is located in La Jolla, California.
QuickLinks -- Click here to rapidly navigate through this documentSenomyx Inc • March 29th, 2004 • Services-commercial physical & biological research • California
THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, OR OTHERWISE TRANSFERRED WITHOUT AN EFFECTIVE REGISTRATION THEREOF UNDER SUCH ACT OR PURSUANT TO RULE 144 OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE CORPORATION AND ITS COUNSEL, THAT SUCH REGISTRATION IS NOT REQUIRED.
SENOMYX, INC. FOURTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT November 14, 2001Investor Rights Agreement • March 29th, 2004 • Senomyx Inc • Services-commercial physical & biological research • California
THIS FOURTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the "Agreement") is entered into as of November 14, 2001, by and among SENOMYX, INC., a Delaware corporation (the "Company"), the holders of the Company's Series A Preferred Stock ("Series A Preferred") acquired pursuant to the Series A Preferred Stock Purchase Agreement dated October 1, 1999 (the "Series A Agreement") the holders of the Company's Series B Preferred Stock ("Series B Preferred") acquired pursuant to the Series B Preferred Stock Purchase Agreement dated August 10, 2000 (the "Series B Agreement"), the holder of the Company's Series C Preferred Stock ("Series C Preferred") acquired pursuant to the Series C Preferred Stock Purchase Agreement dated November 9, 2000 (the "Series C Agreement"), the holder (the "Series D Investor") of the Company's Series D Preferred Stock ("Series D Preferred") acquired pursuant to the Series D Preferred Stock Purchase Agreement dated January 9, 2001 (the "Series D Agreement"), the ho
AMBRYX LOGO] 11099 N. Torrey Pines Road, Suite 160 La Jolla, CA 92037 Telephone: 858-404-0740 Facsimile: 858-404-0750 February 21, 2000 Dr. Mark J. Zoller 7 Sutton Place Weston, MA 02193 Telephone: 781-894-6190 Dear Mark:Senomyx Inc • March 29th, 2004 • Services-commercial physical & biological research
It is my pleasure to provide you with this letter, a formal offer, setting forth the principal terms for you to join Ambryx Inc., a Delaware corporation (the "Company"), which is located in La Jolla, California.
