0001047469-03-039614 Sample Contracts

Up to $575,000,000 Aggregate Principal Amount of 1% Convertible Senior Notes due 2023
Indenture • December 5th, 2003 • Medimmune Inc /De • Biological products, (no disgnostic substances) • New York

FIRST SUPPLEMENTAL INDENTURE, dated as of December 5, 2003 (the "First Supplemental Indenture"), between MEDIMMUNE, INC., a Delaware corporation (the "Company"), and THE BANK OF NEW YORK, a New York banking corporation, as Trustee (the "Trustee").

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