0001047469-03-020056 Sample Contracts

AGREEMENT REGARDING JOINT FILING
BVF Partners L P/Il • May 29th, 2003 • Pharmaceutical preparations

The undersigned, Biotechnology Value Fund, L.P., a Delaware limited partnership, Biotechnology Value Fund II, L.P., a Delaware limited partnership, BVF Investments, L.L.C., a Delaware limited liability company, BVF Partners L.P., a Delaware limited partnership, Investment 10, L.L.C., an Illinois limited liability company and BVF Inc., a Delaware corporation, hereby agree and acknowledge that the information required by the Amendment to Schedule 13G, to which this Agreement is attached as an exhibit, is filed on behalf of each of them. The undersigned further agree that any amendments or supplements thereto shall also be filed on behalf of each of them.

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