0001021408-03-004445 Sample Contracts

OPTION AGREEMENT
Option Agreement • March 18th, 2003 • Adolor Corp • Pharmaceutical preparations • Delaware

This confirms your grant, which occurred on the 22nd day of April, 2002, of an option (this “Option”) to purchase 340,000 shares of common stock, par value $0.0001 per share (a “Share”), of Adolor Corporation, a Delaware corporation (the “Company”) at the price of $14.81 per Share (the “Exercise Price”). This is a nonqualified option, which is subject to the terms and conditions of this Option Agreement.

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AGREEMENT Background
Agreement • March 18th, 2003 • Adolor Corp • Pharmaceutical preparations • Pennsylvania

Adolor Corporation (the “Company”) and Bruce A. Peacock (“Executive”) have entered into a letter agreement dated April 22, 2002 (the “Letter Agreement”) pursuant to which the Company has employed Executive as President, Chief Executive Officer and a member of the Board of Directors of the Company. The Company desires to encourage the highest level of performance by Executive by providing Executive a proprietary interest in the Company’s success and progress. Accordingly, pursuant to the terms of the Letter Agreement, the Company has determined to grant Executive 5,000 shares of the Company’s common stock, subject to the restrictions set forth herein. Therefore, the Company and Executive, both intending to be legally bound, hereby agree as follows:

AMENDED AND RESTATED BUILD TO SUIT LEASE FOR COMBINATION LAB/OFFICE SPACE AT 700 PENNSYLVANIA DRIVE UPPER UWCHLAN TOWNSHIP, CHESTER COUNTY, PA LANDLORD: 700 PENNSYLVANIA DRIVE ASSOCIATES TENANT: ADOLOR CORPORATION 620 Pennsylvania Drive Exton, PA...
Amended and Restated Lease • March 18th, 2003 • Adolor Corp • Pharmaceutical preparations • Pennsylvania

THIS AMENDED AND RESTATED LEASE AGREEMENT (the “Restated Lease”), made this 27th day of February, 2003 between 700 PENNSYLVANIA DRIVE ASSOCIATES (“Landlord”) and ADOLOR CORPORATION (“Tenant”).

AMENDED AND RESTATED SUBLEASE AGREEMENT
Amended and Restated Sublease Agreement • March 18th, 2003 • Adolor Corp • Pharmaceutical preparations • Pennsylvania

THIS AMENDED AND RESTATED SUBLEASE AGREEMENT (“Agreement”) is made this 18th day of April, 2002, by and between Environ Products, Inc., a Pennsylvania corporation with a principal place of business at PO Box 330, 3250 U.S. HWY 70, West, Smithfield, NC 27577 (“Sublessor”), and Adolor Corporation, a Delaware corporation with a principal place of business at 620 Pennsylvania Drive, Exton, PA 19341 (“Sublessee”).

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