0000950144-07-002193 Sample Contracts

February 14, 2007 Jon Stonehouse 7 Pine Top Place Durham, NC 27705 Dear Mr. Stonehouse:
Biocryst Pharmaceuticals Inc • March 14th, 2007 • Biological products, (no disgnostic substances) • Alabama

This amended and restated letter agreement (the “Agreement”) will serve to confirm our agreement with respect to the terms and conditions of your employment with BioCryst Pharmaceuticals, Inc. (“BioCryst” or the “Company”). As you know, this Agreement is identical in all respects to the agreement originally executed on January 5, 2007, except that it reflects the fact that all of the initial equity awards under Section 3 were issued under the BioCryst Pharmaceuticals, Inc. Stock Incentive Plan.

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