0000950135-08-001816 Sample Contracts

STRATEGIC COLLABORATION AGREEMENT BETWEEN EPIX MEDICAL, INC. AND SCHERING AKTIENGESELLSCHAFT DATED AS OF JUNE 9, 2000
Strategic Collaboration Agreement • March 17th, 2008 • EPIX Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

THIS STRATEGIC COLLABORATION AGREEMENT dated as of JUNE 9, 2000 (the “Agreement”) is made by and between EPIX MEDICAL, INC., a Delaware corporation having its principal place of business at 71 Rogers Street, Cambridge, Massachusetts 02142-1118 USA (“EPIX”), and SCHERING AKTIENGESELLSCHAFT, a German corporation having its principal place of business at 13342, Berlin, Germany (“Schering”).

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AMENDMENT NO. 1 TO STRATEGIC COLLABORATION AGREEMENT
Strategic Collaboration Agreement • March 17th, 2008 • EPIX Pharmaceuticals, Inc. • Pharmaceutical preparations

This Amendment No. 1 to the STRATEGIC COLLABORATION AGREEMENT effective as of December 22, 2001 (the “Effective Date”) is made by and between EPIX MEDICAL, INC., a Delaware corporation having its principal place of business at 71 Rogers Street, Cambridge, Massachusetts 02142-118 USA (“EPIX”), and SCHERING AKTIENGESELLSCHAFT, a German corporation having its principal place of business at 13342, Berlin, Germany (“Schering”).

AMENDED AND RESTATED STRATEGIC COLLABORATION AGREEMENT AMONG EPIX MEDICAL, INC. MALLINCKRODT INC. (a Delaware corporation) AND MALLINCKRODT INC. (a New York corporation) DATED AS OF JUNE 9, 2000
Strategic Collaboration Agreement • March 17th, 2008 • EPIX Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

THIS AMENDED AND RESTATED STRATEGIC COLLABORATION AGREEMENT dated as of June 9, 2000 (the “Agreement”) is made by and among EPIX MEDICAL, INC. (formerly known as Metasyn, Inc.), a Delaware corporation having its principal place of business at 71 Rogers Street, Cambridge, Massachusetts 02142-1118 U.S.A. (“EPIX”), MALLINCKRODT INC. (formerly known as Mallinckrodt Medical, Inc.), a Delaware corporation having its principal place of business at 675 McDonnell Boulevard, Hazelwood, Missouri 63042 and MALLLNCKRODT INC. (formerly known as Mallinckrodt Group Inc.), a New York corporation having its principal place of business at 675 McDonnell Boulevard, Hazelwood, Missouri 63042 (both MALLINCKRODT entities referred to collectively herein as “MKG”), and amends and restates, from and after the date hereof, the Strategic Collaboration Agreement dated as of August 30, 1996 (as twice amended on September 10, 1998 and July 9, 1999) between MKG and METASYN (the predecessor in interest of EPIX).

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