0000950135-07-006762 Sample Contracts

COOPERATIVE DEVELOPMENT AGREEMENT
Cooperative Development Agreement • November 7th, 2007 • Altus Pharmaceuticals Inc. • Biological products, (no disgnostic substances)

THIS AGREEMENT, entered into as of the 8th day of November, 2002, by and between ALTUS BIOLOGICS INC., a corporation organized and existing under the laws of the State of Delaware and having its principal place of business at 625 Putnam Avenue, Cambridge, MA 02139 (hereinafter called “ALTUS”), and AMANO ENZYME INC., a corporation organized and existing under the laws of Japan and having its principal place of business at 1-2-7, Nishiki, Naka-ku, Nagoya, Japan (hereinafter called “AMANO”),

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Amendment No. 3 to Cooperative Development Agreement
Development Agreement • November 7th, 2007 • Altus Pharmaceuticals Inc. • Biological products, (no disgnostic substances)

THIS AMENDMENT, entered into as of 12th day of July, 2007 (this “Amendment”) by and between ALTUS PHARMACEUTICALS INC. , a corporation organized and existing under the laws of the State of Delaware and having its principal place of business at 125 Sidney Street, Cambridge, MA 02139, USA (hereinafter called “ALTUS”), and AMANO ENZYME INC. , a corporation organized and existing under the laws of Japan and having its principal place of business at 1-2-7, Nishiki, Naka-ku, Nagoya, Japan (hereinafter called “AMANO”), amends the Cooperative Development Agreement dated as of November 8, 2002, by and between Altus and Amano (the “Agreement”). Capitalized terms used in this Amendment and not defined in this Amendment shall have the meanings ascribed to them in the Agreement.

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