0000950133-07-000143 Sample Contracts

VANDA PHARMACEUTICALS INC. 3,500,000 Shares of Common Stock Underwriting Agreement
Vanda Pharmaceuticals Inc. • January 17th, 2007 • Pharmaceutical preparations • New York

Vanda Pharmaceuticals Inc., a Delaware corporation (the “Company”), proposes to issue and sell to the several Underwriters listed in Schedule 1 hereto (the “Underwriters”), for whom you are acting as representatives (the “Representatives”), an aggregate of 3,500,000 shares of Common Stock, par value $0.001 per share, of the Company (the “Underwritten Shares” and, at the option of the Underwriters, up to an additional 525,000 shares of Common Stock of the Company (the “Option Shares”). The Underwritten Shares and the Option Shares are herein referred to as the “Shares”). The shares of Common Stock of the Company to be outstanding after giving effect to the sale of the Shares are herein referred to as the “Stock”.

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