0000950129-07-003865 Sample Contracts

PURCHASE OPTION AGREEMENT by and among LEXICON PHARMACEUTICALS, INC. SYMPHONY ICON HOLDINGS LLC and SYMPHONY ICON, INC. Dated as of June 15, 2007

Purchase Option Agreement • August 8th, 2007 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • Delaware

• Contract Type
  Purchase Option Agreement
• Filed
  August 8th, 2007
• Company
  Lexicon Pharmaceuticals, Inc./De
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

This PURCHASE OPTION AGREEMENT (this “Agreement”) is entered into as of June 15, 2007 (the “Closing Date”), by and among LEXICON PHARMACEUTICALS, INC., a Delaware corporation (“Lexicon”), SYMPHONY ICON HOLDINGS LLC, a Delaware limited liability company (“Holdings”), and SYMPHONY ICON, INC., a Delaware corporation (“Symphony Icon”). Capitalized terms used herein and not defined herein shall have the meanings assigned to such terms in Annex A attached hereto.

AMENDED AND RESTATED RESEARCH AND DEVELOPMENT AGREEMENT among LEXICON PHARMACEUTICALS, INC. SYMPHONY ICON HOLDINGS LLC and SYMPHONY ICON, INC. Dated as of June 15, 2007

Research and Development Agreement • August 8th, 2007 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • Delaware

• Contract Type
  Research and Development Agreement
• Filed
  August 8th, 2007
• Company
  Lexicon Pharmaceuticals, Inc./De
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

This AMENDED AND RESTATED RESEARCH AND DEVELOPMENT AGREEMENT (this “Agreement”) is entered into as of June 15, 2007 (the “Closing Date”) by and among LEXICON PHARMACEUTICALS, INC., a Delaware corporation (“Lexicon”), SYMPHONY ICON, INC., a Delaware corporation (“Symphony Icon”) (each of Lexicon and Symphony Icon being a “Party,” and collectively, the “Parties”), and SYMPHONY ICON HOLDINGS LLC, a Delaware limited liability company (“Holdings”). Capitalized terms used herein and not defined herein shall have the meanings assigned to such terms in Annex A attached hereto.

RESEARCH COST SHARING, PAYMENT AND EXTENSION AGREEMENT

Payment and Extension Agreement • August 8th, 2007 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • Delaware

• Contract Type
  Payment and Extension Agreement
• Filed
  August 8th, 2007
• Company
  Lexicon Pharmaceuticals, Inc./De
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

This RESEARCH COST SHARING, PAYMENT AND EXTENSION AGREEMENT (this “Agreement”) is entered into as of June 15, 2007, by and among LEXICON PHARMACEUTICALS, INC., a Delaware corporation (“Lexicon”), SYMPHONY ICON HOLDINGS LLC, a Delaware limited liability company (“Holdings”), and SYMPHONY ICON, INC., a Delaware corporation (“Symphony Icon”).

NOVATED AND RESTATED TECHNOLOGY LICENSE AGREEMENT dated as of June 15, 2007 among LEXICON PHARMACEUTICALS, INC., SYMPHONY ICON, INC. and SYMPHONY ICON HOLDINGS LLC

Technology License Agreement • August 8th, 2007 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • Delaware

• Contract Type
  Technology License Agreement
• Filed
  August 8th, 2007
• Company
  Lexicon Pharmaceuticals, Inc./De
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

This NOVATED AND RESTATED TECHNOLOGY LICENSE AGREEMENT (this “Agreement”) is made and effective as of June 15, 2007 by and among, Lexicon Pharmaceuticals, Inc., a Delaware corporation (f/k/a Lexicon Genetics Incorporated) (the “Licensor”), Symphony Icon, Inc., a Delaware corporation (“Symphony Icon”) (each of Licensor and Symphony Icon being a “Party,” and collectively, the “Parties”), and Symphony Icon Holdings LLC, a Delaware limited liability company (“Holdings”).