0000950123-14-006436 Sample Contracts

CONFIDENTIAL TREATMENT REQUESTED AMENDMENT TO LICENCE AGREEMENT Made and entered in to this 23rd day of March 2010 By and between YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED
Licence Agreement • May 16th, 2014 • Histogenics Corp • Orthopedic, prosthetic & surgical appliances & supplies

WHEREAS in light of a collaboration agreement entered into between the Company and **** (as hereinafter defined) the parties have agreed to amend the Licence Agreement, as more particularly set out herein.

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CONFIDENTIAL TREATMENT REQUESTED SEVENTH AMENDMENT TO LICENSE AGREEMENT
License Agreement • May 16th, 2014 • Histogenics Corp • Orthopedic, prosthetic & surgical appliances & supplies

Angiotech Pharmaceuticals (US), Inc., a corporation organized and existing under the laws of the State of Washington, with principal offices at North Bend, WA (“Angiotech US”);

CONFIDENTIAL TREATMENT REQUESTED THIRD AMENDMENT TO LICENSE AGREEMENT
License Agreement • May 16th, 2014 • Histogenics Corp • Orthopedic, prosthetic & surgical appliances & supplies

Angiotech Pharmaceuticals (US), Inc., a corporation organized and existing under the laws of the State of Washington, with principal offices at North Bend, WA (“Angiotech US”);

FIRST AMENDMENT TO EXCLUSIVE AGREEMENT
Exclusive Agreement • May 16th, 2014 • Histogenics Corp • Orthopedic, prosthetic & surgical appliances & supplies

This First Amendment, effective as of October 26, 2005, by and between the Board of Trustees of the Leland Stanford Junior University, a body having corporate powers under the laws of the State of California (“Stanford”), and Histogenics Corporation, a Massachusetts corporation (“Histogenics”), serves to amend the Exclusive Agreement between Stanford and Licensee, titled “Restoration of Articular Cartilage Matrix” dated April 15, 2001 and described in Stanford docket S98-181 (the “Agreement”). Stanford and Histogenics agree as follows:

AMENDMENT NO. 4 TO THE LICENSE AGREEMENT EFFECTIVE 04/15/2001 BETWEEN STANFORD UNIVERSITY AND HISTOGENICS CORPORATION
License Agreement • May 16th, 2014 • Histogenics Corp • Orthopedic, prosthetic & surgical appliances & supplies

Effective as of April 29, 2010, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (“Stanford”), an institution of higher education having powers under the laws of the State of California, and Histogenics Corporation, a Delaware corporation having its principal offices at 830 Winter Street, 3rd Floor, Waltham, MA 02451 (“Histogenics”) agrees as follows:

CONFIDENTIAL TREATMENT REQUESTED SECOND AMENDMENT TO LICENSE AGREEMENT
License Agreement • May 16th, 2014 • Histogenics Corp • Orthopedic, prosthetic & surgical appliances & supplies • Delaware

Angiotech Pharmaceuticals (US), Inc., a corporation organized and existing under the laws of the State of Washington, with principal offices at North Bend, WA (“Angiotech US”);

CONFIDENTIAL TREATMENT REQUESTED LICENSE AGREEMENT
License Agreement • May 16th, 2014 • Histogenics Corp • Orthopedic, prosthetic & surgical appliances & supplies • Washington

Angiotech Biomaterials Corp., a corporation organized and existing under the laws of Delaware, with principal offices at 2500 Faber Place, Palo Alto, CA, 94303 (“Biomaterials”);

CONFIDENTIAL TREATMENT REQUESTED FOURTH AMENDMENT TO LICENSE AGREEMENT
License Agreement • May 16th, 2014 • Histogenics Corp • Orthopedic, prosthetic & surgical appliances & supplies

Angiotech Pharmaceuticals (US), Inc., a corporation organized and existing under the laws of the State of Washington, with principal offices at North Bend, WA (“Angiotech US”);

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