0000950123-10-050278 Sample Contracts

AMENDMENT NO. 1 TO RIGHTS AGREEMENT
Rights Agreement • May 17th, 2010 • Osi Pharmaceuticals Inc • In vitro & in vivo diagnostic substances • New York

AMENDMENT NO. 1, dated as of May 16, 2010 (the “Amendment”), to the Rights Agreement, dated as of September 27, 2000 (the “Agreement”), between OSI Pharmaceuticals, Inc., a Delaware corporation (the “Company” or “OSI”), and The Bank of New York Mellon (f/k/a The Bank of New York), a New York banking corporation, as Rights Agent (the “Rights Agent”). Terms used but not otherwise defined herein shall have the meanings ascribed to such respective terms in the Agreement.

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AGREEMENT AND PLAN OF MERGER BY AND AMONG ASTELLAS PHARMA INC., ASTELLAS US HOLDING, INC., RUBY ACQUISITION, INC., AND OSI PHARMACEUTICALS, INC. DATED AS OF MAY 16, 2010
Agreement and Plan of Merger • May 17th, 2010 • Osi Pharmaceuticals Inc • In vitro & in vivo diagnostic substances • Delaware

AGREEMENT AND PLAN OF MERGER, dated as of May 16, 2010 (this “Agreement”), by and among Astellas Pharma Inc., a corporation formed under the laws of Japan (“Parent”), Astellas US Holding, Inc., a Delaware corporation and a wholly-owned subsidiary of the Parent, Ruby Acquisition, Inc., a Delaware corporation and a direct wholly-owned subsidiary of Holding and an indirect wholly-owned subsidiary of Parent (“Merger Sub”), and OSI Pharmaceuticals, Inc. a Delaware corporation (the “Company”).

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