0000950123-09-033028 Sample Contracts

The Medicines Company requests that the marked portions of the agreement be granted confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934. AMENDMENT NO. 1 TO AMENDED AND RESTATED DISTRIBUTION AGREEMENT
Distribution Agreement • August 10th, 2009 • Medicines Co /De • Pharmaceutical preparations

This is Amendment No. 1 (this “Amendment”) to the Amended and Restated Distribution Agreement, effective as of February 28, 2007, between The Medicines Company, a Delaware corporation with offices at 8 Campus Drive, Parsippany, NJ 07054 (“TMC”), and Integrated Commercialization Solutions, Inc., a California corporation with offices at 3101 Gaylord Parkway, Frisco, TX 75034 (the “Distributor”). This Amendment is effective as of November 7, 2007 (the “Effective Date”).

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The Medicines Company requests that the marked portions of the agreement be granted confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934. AMENDMENT NO. 2 TO AMENDED AND RESTATED DISTRIBUTION AGREEMENT
Distribution Agreement • August 10th, 2009 • Medicines Co /De • Pharmaceutical preparations

This is Amendment No. 2 (this “Amendment”) to the Amended and Restated Distribution Agreement, effective as of February 28, 2007, between The Medicines Company, a Delaware corporation with offices at 8 Campus Drive, Parsippany, NJ 07054 (“TMC”), and Integrated Commercialization Solutions, Inc., a California corporation with offices at 3101 Gaylord Parkway, Frisco, TX 75034 (the “Distributor”). This Amendment is effective as of October 1, 2008 (the “Effective Date”).

The Medicines Company requests that the marked portions of the agreement be granted confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934. AMENDED AND RESTATED DISTRIBUTION AGREEMENT
Distribution Agreement • August 10th, 2009 • Medicines Co /De • Pharmaceutical preparations • New York

This Amended and Restated Distribution Agreement (together with its schedules and exhibits, the “Agreement”) is entered into by The Medicines Company, a Delaware corporation with offices at 8 Campus Drive, Parsippany, NJ 07054 (“TMC”), and Integrated Commercialization Solutions, Inc., a California corporation with offices at 4006 Belt Line Road, Suite 100, Addison, TX 75001 (the “Distributor”), effective as of February 28, 2007 (the “Effective Date”).

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