0000950123-06-008002 Sample Contracts

June 14, 2006 Amended June 21, 2006
Osi Pharmaceuticals Inc • June 22nd, 2006 • In vitro & in vivo diagnostic substances • New York

This letter is to confirm our understanding with respect to (i) your continuing employment by OSI Pharmaceuticals, Inc. (“OSI” and, together with Company Affiliates (as defined below), the “Company”), (ii) your agreement not to solicit employees or customers of the Company or any Company Affiliate, (iii) your agreement to protect and preserve information and property which is confidential and proprietary to the Company, and (iv) your agreement with respect to the ownership of inventions, ideas, copyrights and patents which may be used in the business of the Company (the terms and conditions agreed to in this letter are hereinafter referred to as the “Agreement”). As used herein, any presently existing parent, subsidiary or affiliate of OSI is referred to as a “Company Affiliate.” In consideration of the mutual promises and covenants contained in this Agreement, and for other good and valuable consideration, the receipt and sufficiency of which are hereby mutually acknowledged, we have

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OSI PHARMACEUTICALS, INC. STOCK OPTION AGREEMENT
Incentive and Non-Qualified Stock Option Plan • June 22nd, 2006 • Osi Pharmaceuticals Inc • In vitro & in vivo diagnostic substances • New York

THIS NON-QUALIFIED STOCK OPTION AGREEMENT is dated as of ___, 2006 by and between OSI PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and [Executive Officer] (the “Optionee”), an employee of the Company.

OSI PHARMACEUTICALS, INC.
Incentive and Non-Qualified Stock Option Plan Agreement • June 22nd, 2006 • Osi Pharmaceuticals Inc • In vitro & in vivo diagnostic substances • England and Wales

THIS NON-QUALIFIED STOCK OPTION (this “Option”) is dated as of June 21, 2006, by OSI PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), to [Employee] (the “Optionee”), an employee of Prosidion Limited (“the UK Subsidiary”). The Option is granted subject to a condition that any liability of the UK Subsidiary (as employer or former employer of the Optionee) to pay secondary national insurance contributions (“Secondary NIC”) in respect of the exercise, assignment or release of the Option shall be the liability of the Optionee and payable by the Optionee and that the Optionee shall be required to enter into an election in the form envisaged in Paragraph 313(1) of Schedule 1 to the Social Security Contributions and Benefits Act 1992 (“Election”) to that effect when required to do so by the UK Subsidiary provided that the Committee may in its discretion at any time or times release the Optionee from this liability or reduce his liability thereunder unless that Election has been e

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