0000950123-05-010167 Sample Contracts

August 21, 2005 David R. Guyer, M.D. Dear David:
Osi Pharmaceuticals Inc • August 22nd, 2005 • In vitro & in vivo diagnostic substances • New York

This letter is to confirm our understanding with respect to your continued employment with (OSI) Eyetech, Inc., formerly known as Eyetech Pharmaceuticals, Inc. (the “Company”), following the consummation of the merger described in the Agreement and Plan of Merger (“Merger Agreement”) among OSI Pharmaceuticals, Inc. (the “Parent”), Merger Sub and Eyetech Pharmaceuticals, Inc., and your future employment with Parent. If the Merger Agreement is terminated in accordance with its terms, this Agreement shall immediately terminate. You acknowledge and understand that upon the consummation of the merger, the Company will be a wholly-owned subsidiary of Parent.

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