IF THIS NOTE IS TO BE A GLOBAL SECURITY, INSERT:]Shire PLC • September 21st, 2016 • Pharmaceutical preparations
THIS NOTE IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), OR A NOMINEE OF DTC. THIS NOTE IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN DTC OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE AND MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY DTC TO A NOMINEE OF DTC, OR BY A NOMINEE OF DTC TO DTC OR ANOTHER NOMINEE OF DTC.
Shire Acquisitions Investments Ireland DAC $3,300,000,000 1.900% Senior Notes due 2019 $3,300,000,000 2.400% Senior Notes due 2021 $2,500,000,000 2.875% Senior Notes due 2023 $3,000,000,000 3.200% Senior Notes due 2026 Underwriting AgreementShire PLC • September 21st, 2016 • Pharmaceutical preparations • New York
Shire Acquisitions Investments Ireland DAC, a designated activity company organized under the laws of Ireland (the “Issuer”), proposes to sell to the several underwriters named in Schedule II hereto (the “Underwriters”), for whom you (the “Representatives”) are acting as representatives, the principal amount of its securities identified in Schedule I hereto (the “Securities”), to be issued under an indenture (the “Base Indenture”) dated as of September 23, 2016, among the Issuer, Shire plc, a company incorporated in Jersey (the “Company”), and Deutsche Bank Trust Company Americas, as trustee (the “Trustee”), as supplemented by a supplemental indenture (the “Supplemental Indenture” and, together with the Base Indenture, the “Indenture”) dated as of September 23, 2016, among the Issuer, the Company and the Trustee. The Securities will be fully and unconditionally guaranteed (the “Guarantee”) by the Company. To the extent there are no additional Underwriters listed on Schedule II other th
