0000950103-05-002385 Sample Contracts

Deposit Agreement Dated as of November 21, 2005
Deposit Agreement • November 25th, 2005 • Shire PLC • Pharmaceutical preparations

DEPOSIT AGREEMENT dated as of November 21, 2005 (the "Deposit Agreement") among SHIRE plc and its successors (the "Company"), JPMORGAN CHASE BANK, N.A., as depositary hereunder (the "Depositary"), and all holders from time to time of American Depositary Receipts issued hereunder ("ADRs") evidencing American Depositary Shares ("ADSs") representing deposited Shares (defined below).

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THIS AMENDMENT AGREEMENT is made the day of November, 2005 BETWEEN:
Agreement • November 25th, 2005 • Shire PLC • Pharmaceutical preparations
Sample 1
RATIFICATION AND GUARANTY RELATING TO THE SERVICE CONTRACT OF MR MATTHEW EMMENS
Shire PLC • November 25th, 2005 • Pharmaceutical preparations
Sample 1
Form of Indemnity Deed for Directors of Shire plc]
Shire PLC • November 25th, 2005 • Pharmaceutical preparations
Sample 1
THIS NOVATION AGREEMENT is made the day of November, 2005 BETWEEN:
Novation Agreement • November 25th, 2005 • Shire PLC • Pharmaceutical preparations • England
Sample 1
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