0000945234-08-000133 Sample Contracts

DEVELOPMENT AND LICENSE AGREEMENT BETWEEN CARDIOME DEVELOPMENT LTD. AND ELI LILLY AND COMPANY SIGNED AS OF APRIL 30, 2007
Development and License Agreement • March 28th, 2008 • Cardiome Pharma Corp • Pharmaceutical preparations

This DEVELOPMENT AND LICENSE AGREEMENT (the “Agreement”) is entered into as of April 30, 2007, by and between Eli Lilly and Company, a corporation, incorporated under the laws of the State of Indiana, having its principal place of business at Lilly Corporate Center, Indianapolis, Indiana USA, 46285, and its Affiliates (hereinafter collectively referred to as “Lilly”), and Cardiome Development Ltd., a corporation incorporated under the laws of British Columbia, Canada, having its principal place of business at 6190 Agronomy Drive, 6th Floor, Vancouver, B.C., Canada, V6T 1Z3, (“Cardiome”). Lilly and Cardiome shall sometimes hereinafter be individually referred to as a “Party” and collectively referred to as the “Parties”). The Parties agree as follows:

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AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • March 28th, 2008 • Cardiome Pharma Corp • Pharmaceutical preparations

This Amendment, effective July ___, 2006, (this “Amendment”) is made by and between Cardiome Pharma Corp., a Canadian corporation having its offices at 3650 Wesbrook Mall, Vancouver, BC, Canada V6S 2L2 and Cardiome Research and Development (Barbados) Inc. (collectively, “Cardiome”), and Astellas US LLC, a Delaware limited liability company having its principal place of business at Three Parkway North, Deerfield, IL, USA 60015-2548 (“Astellas”), a successor to Fujisawa Healthcare, Inc.

CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS EXHIBIT, WHICH PORTIONS HAVE BEEN OMITTED AND REPLACED WITH “REDACTED” AND A SUMMARY OF THE REDACTED LANGUAGE. COLLABORATION AND LICENSE AGREEMENT BY AND BETWEEN CARDIOME PHARMA...
Stock Purchase Agreement • March 28th, 2008 • Cardiome Pharma Corp • Pharmaceutical preparations • Delaware

NOW, THEREFORE, in consideration of the foregoing Recitals and the mutual covenants and agreements contained herein, the Parties hereby agree as follows:

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