0000944809-18-000014 Sample Contracts

AMENDMENT NO. 6 TO CREDIT AGREEMENT
Credit Agreement • March 1st, 2018 • Opko Health, Inc. • Pharmaceutical preparations • New York

AMENDMENT NO. 6 TO CREDIT AGREEMENT (this “Amendment”), dated as of December 22, 2017, is entered into among BIO-REFERENCE LABORATORIES, INC., a New Jersey corporation (“Company”), the Subsidiary Borrowers party hereto (“Subsidiary Borrowers,” and together with Company, each a “Borrower” and, collectively, the “Borrowers”), the other Loan Parties party hereto, the Lenders party hereto, and JPMORGAN CHASE BANK, N.A., as the administrative agent for the Lenders (the “Administrative Agent”).

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DEVELOPMENT AND LICENSE AGREEMENT BETWEEN EIRGEN PHARMA LIMITED AND JAPAN TOBACCO INC. October 12, 2017
Development and License Agreement • March 1st, 2018 • Opko Health, Inc. • Pharmaceutical preparations • New York

This Development and License Agreement (this “Agreement”) is entered into and effective as of the 12th day of October, 2017 (the “Effective Date”), by and between EirGen Pharma Limited, an entity formed under the laws of Ireland with registered seat at Westside Business, Old Kilmeaden, Waterford, Ireland (“OPKO”), which is an indirect wholly-owned subsidiary of OPKO Health, Inc., a Delaware corporation, on the one hand, and Japan Tobacco Inc., a corporation formed under the laws of Japan with registered seat at JT Building, 2-1, Toranomon 2-chome, Minato-ku, Tokyo 105-8422, Japan (“Licensee”), on the other hand. OPKO and Licensee are each referred to herein by name or as a “Party” or, collectively, as “Parties.”

AMENDMENT NO. 5 TO CREDIT AGREEMENT
Credit Agreement • March 1st, 2018 • Opko Health, Inc. • Pharmaceutical preparations • New York

AMENDMENT NO. 5 TO CREDIT AGREEMENT (this “Amendment”), dated as of November 8, 2017, is entered into among BIO-REFERENCE LABORATORIES, INC., a New Jersey corporation (“Company”), the Subsidiary Borrowers party hereto (“Subsidiary Borrowers,” and together with Company, each a “Borrower” and, collectively, the “Borrowers”), the other Loan Parties party hereto, the Lenders party hereto, and JPMORGAN CHASE BANK, N.A., as the administrative agent for the Lenders (the “Administrative Agent”).

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